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Title: Gd(III) complexes intercalated into hydroxy double salts as potential MRI contrast agents
Author(s): Bligh, Annie Sim Wan 
Author(s): Jin, M.
Spillane, D. E. M.
Geraldes, C. F. G. C.
Williams, G. R.
Issue Date: 2015
Publisher: Royal Society of Chemistry
Journal: Dalton Transactions 
Volume: 44
Issue: 47
Start page: 20728
End page: 20734
The ion exchange intercalation of two Gd-based magnetic resonance imaging contrast agents into hydroxy double salts (HDSs) is reported. The presence of Gd3+ diethylenetriaminepentaacetate and Gd3+ diethylenetriaminepenta(methylenephosphonate) complexes in the HDS lattice after intercalation was confirmed by microwave plasma-atomic emission spectroscopy. The structural aspects of the HDS-Gd composites were studied by X-ray diffraction, with the intercalates having an interlayer spacing of 14.5–18.6 Å. Infrared spectroscopy confirmed the presence of characteristic vibration peaks associated with the Gd3+ complexes in the intercalation compounds. The proton relaxivities of the Gd3+ complex-loaded composites were 2 to 5-fold higher in longitudinal relaxivity, and up to 10-fold higher in transverse relaxivity, compared to solutions of the pure complexes. These data demonstrate that the new composites reported here are potentially potent MRI contrast agents.
DOI: 10.1039/C5DT03433G
CIHE Affiliated Publication: No
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