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https://repository.cihe.edu.hk/jspui/handle/cihe/1735| Title: | Presentation of the β-carboxamidophosphonate arrangement in substrate structures targeting HIV-1 PR | Author(s): | Bligh, Annie Sim Wan | Author(s): | Wardle, N. J. Hudson, H. R. Matthews, R. W. Nunn, C. Vella, C. |
Issue Date: | 2009 | Publisher: | Bentham Science | Journal: | Letters in Drug Design & Discovery | Volume: | 6 | Issue: | 2 | Start page: | 139 | End page: | 145 | Abstract: | Novel O,O-diethyl 1-benzamido-2,2-biscarbamoylethanephosphonates were synthesised as putative substrates to HIV-1 PR, to exploit the state of activation of the phosphonate electrophilic function in β-carboxamidophosphonate arrangements. O,O-Diethyl 1-benzamido-2,2-bis[(1S)-N-(1-benzyl-2-hydroxyethyl)carbamoyl]ethanephosphonate exhibited moderate anti-HIV activity in vitro (EC50 = 53 μrbamoyl]ethanephosphonate inhibited HIV-1 PR (IC50 = 31 μM). |
URI: | https://repository.cihe.edu.hk/jspui/handle/cihe/1735 | DOI: | 10.2174/157018009787582660 | CIHE Affiliated Publication: | No |
| Appears in Collections: | HS Publication |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Check Library Catalogue | 115 B | HTML | View/Open |
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