Please use this identifier to cite or link to this item:
https://repository.cihe.edu.hk/jspui/handle/cihe/1735| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Bligh, Annie Sim Wan | en_US |
| dc.contributor.other | Wardle, N. J. | - |
| dc.contributor.other | Hudson, H. R. | - |
| dc.contributor.other | Matthews, R. W. | - |
| dc.contributor.other | Nunn, C. | - |
| dc.contributor.other | Vella, C. | - |
| dc.date.accessioned | 2021-11-15T05:23:47Z | - |
| dc.date.available | 2021-11-15T05:23:47Z | - |
| dc.date.issued | 2009 | - |
| dc.identifier.uri | https://repository.cihe.edu.hk/jspui/handle/cihe/1735 | - |
| dc.description.abstract | Novel O,O-diethyl 1-benzamido-2,2-biscarbamoylethanephosphonates were synthesised as putative substrates to HIV-1 PR, to exploit the state of activation of the phosphonate electrophilic function in β-carboxamidophosphonate arrangements. O,O-Diethyl 1-benzamido-2,2-bis[(1S)-N-(1-benzyl-2-hydroxyethyl)carbamoyl]ethanephosphonate exhibited moderate anti-HIV activity in vitro (EC50 = 53 μrbamoyl]ethanephosphonate inhibited HIV-1 PR (IC50 = 31 μM). | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Bentham Science | en_US |
| dc.relation.ispartof | Letters in Drug Design & Discovery | en_US |
| dc.title | Presentation of the β-carboxamidophosphonate arrangement in substrate structures targeting HIV-1 PR | en_US |
| dc.type | journal article | en_US |
| dc.identifier.doi | 10.2174/157018009787582660 | - |
| dc.contributor.affiliation | School of Health Sciences | en_US |
| dc.relation.issn | 1875-628X | en_US |
| dc.description.volume | 6 | en_US |
| dc.description.issue | 2 | en_US |
| dc.description.startpage | 139 | en_US |
| dc.description.endpage | 145 | en_US |
| dc.cihe.affiliated | No | - |
| item.fulltext | With Fulltext | - |
| item.grantfulltext | open | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
| item.cerifentitytype | Publications | - |
| item.openairetype | journal article | - |
| item.languageiso639-1 | en | - |
| crisitem.author.dept | S.K. Yee School of Health Sciences | - |
| crisitem.author.orcid | 0000-0002-4757-2159 | - |
| Appears in Collections: | HS Publication | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Check Library Catalogue | 115 B | HTML | View/Open |
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