Please use this identifier to cite or link to this item: https://repository.cihe.edu.hk/jspui/handle/cihe/1735
DC FieldValueLanguage
dc.contributor.authorBligh, Annie Sim Wanen_US
dc.contributor.otherWardle, N. J.-
dc.contributor.otherHudson, H. R.-
dc.contributor.otherMatthews, R. W.-
dc.contributor.otherNunn, C.-
dc.contributor.otherVella, C.-
dc.date.accessioned2021-11-15T05:23:47Z-
dc.date.available2021-11-15T05:23:47Z-
dc.date.issued2009-
dc.identifier.urihttps://repository.cihe.edu.hk/jspui/handle/cihe/1735-
dc.description.abstractNovel O,O-diethyl 1-benzamido-2,2-biscarbamoylethanephosphonates were synthesised as putative substrates to HIV-1 PR, to exploit the state of activation of the phosphonate electrophilic function in β-carboxamidophosphonate arrangements. O,O-Diethyl 1-benzamido-2,2-bis[(1S)-N-(1-benzyl-2-hydroxyethyl)carbamoyl]ethanephosphonate exhibited moderate anti-HIV activity in vitro (EC50 = 53 μrbamoyl]ethanephosphonate inhibited HIV-1 PR (IC50 = 31 μM).en_US
dc.language.isoenen_US
dc.publisherBentham Scienceen_US
dc.relation.ispartofLetters in Drug Design & Discoveryen_US
dc.titlePresentation of the β-carboxamidophosphonate arrangement in substrate structures targeting HIV-1 PRen_US
dc.typejournal articleen_US
dc.identifier.doi10.2174/157018009787582660-
dc.contributor.affiliationSchool of Health Sciencesen_US
dc.relation.issn1875-628Xen_US
dc.description.volume6en_US
dc.description.issue2en_US
dc.description.startpage139en_US
dc.description.endpage145en_US
dc.cihe.affiliatedNo-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypejournal article-
item.fulltextWith Fulltext-
crisitem.author.deptSchool of Health Sciences-
crisitem.author.orcid0000-0002-4757-2159-
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