Please use this identifier to cite or link to this item:
https://repository.cihe.edu.hk/jspui/handle/cihe/1502| Title: | Enhanced replication of R5 HIV-1 isolates in vitro by a small-molecule reagent targeting HIV-1 protease | Author(s): | Bligh, Annie Sim Wan | Author(s): | Wardle, N. J. Hudson, H. R. Matthews, R. W. Nunn, C. M. Vella, C. |
Issue Date: | 2013 | Publisher: | Wiley | Journal: | ChemMedChem | Volume: | 8 | Issue: | 5 | Start page: | 719 | End page: | 721 | Abstract: | Chemical enhancement: Designed to target HIV-1 protease, a novel γ-hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV-1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it has implications for the preparation and use of R5 isolates in vaccine and drug development. |
URI: | https://repository.cihe.edu.hk/jspui/handle/cihe/1502 | DOI: | 10.1002/cmdc.201300051 | CIHE Affiliated Publication: | No |
| Appears in Collections: | HS Publication |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Check Library Catalogue | 115 B | HTML | View/Open |
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