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Title: Enhanced replication of R5 HIV-1 isolates in vitro by a small-molecule reagent targeting HIV-1 protease
Author(s): Bligh, Annie Sim Wan 
Author(s): Wardle, N. J.
Hudson, H. R.
Matthews, R. W.
Nunn, C. M.
Vella, C.
Issue Date: 2013
Publisher: Wiley
Journal: ChemMedChem 
Volume: 8
Issue: 5
Start page: 719
End page: 721
Chemical enhancement: Designed to target HIV-1 protease, a novel γ-hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV-1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it has implications for the preparation and use of R5 isolates in vaccine and drug development.
DOI: 10.1002/cmdc.201300051
CIHE Affiliated Publication: No
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