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|Title:||Enhanced replication of R5 HIV-1 isolates in vitro by a small-molecule reagent targeting HIV-1 protease||Author(s):||Bligh, Annie Sim Wan||Author(s):||Wardle, N. J.
Hudson, H. R.
Matthews, R. W.
Nunn, C. M.
|Issue Date:||2013||Publisher:||Wiley||Journal:||ChemMedChem||Volume:||8||Issue:||5||Start page:||719||End page:||721||Abstract:||
Chemical enhancement: Designed to target HIV-1 protease, a novel γ-hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV-1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it has implications for the preparation and use of R5 isolates in vaccine and drug development.
|URI:||https://repository.cihe.edu.hk/jspui/handle/cihe/1502||DOI:||10.1002/cmdc.201300051||CIHE Affiliated Publication:||No|
|Appears in Collections:||HS Publication|
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