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Title: Nanofibers fabricated using triaxial electrospinning as zero order drug delivery systems
Author(s): Bligh, Annie Sim Wan 
Author(s): Yu, D.-G.
Li, X.-Y.
Wang, X.
Yang, J.-H.
Williams, G. R.
Issue Date: 2015
Publisher: ACS Publications
Journal: ACS Applied Materials & Interfaces 
Volume: 7
Issue: 33
Start page: 18891
End page: 18897
A new strategy for creating functional trilayer nanofibers through triaxial electrospinning is demonstrated. Ethyl cellulose (EC) was used as the filament-forming matrix in the outer, middle, and inner working solutions and was combined with varied contents of the model active ingredient ketoprofen (KET) in the three fluids. Triaxial electrospinning was successfully carried out to generate medicated nanofibers. The resultant nanofibers had diameters of 0.74 ± 0.06 μm, linear morphologies, smooth surfaces, and clear trilayer nanostructures. The KET concentration in each layer gradually increased from the outer to the inner layer. In vitro dissolution tests demonstrated that the nanofibers could provide linear release of KET over 20 h. The protocol reported in this study thus provides a facile approach to creating functional nanofibers with sophisticated structural features.
DOI: 10.1021/acsami.5b06007
CIHE Affiliated Publication: No
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