Can saturation of oxygen and heart rate variations predict the intradialytic hypotension occurrence?

Abstract

Background Intradialytic hypotension is a common symptom among end stage renal disease patients in haemodialysis. It occurred during haemodialysis and might cause severe or life-threatening complications. No effective pre-occurrence alarm system has been developed for monitoring patients’ conditions at this time. It was found that variations of saturation of oxygen and heart rate were associated with intradialytic hypotension occurrence. These two signals might be used as predictors for detecting intradialytic hypotension occurrence.

Methods Sixty-eight patients of end stage renal disease who required temporary or long-term haemodialysis treatment were recruited. Intradialytic hypotension was defined as having a decrease in systolic blood pressure by at least 30mmHg below the predialysis measurement or to a systolic value below 100 mmHg. Oxygen saturation data and heart rate during their haemodialysis sessions were collected, and analyzed by sequence alignment and Boolean algebra.

Results Data in variations of oxygen saturation and heart rate were classified into three ,Classifiers which were developed as predictors for determining pre-occurrence of intradialytic hypotension within 30 minutes. The sensitivity and specificity of these Classifiers for the prediction of intradialytic hypotension occurrence were found to be over 80%.

Conclusion/Application to practice The results suggested that variations of saturation of oxygen and heart rate could be used as predictors for developing an alarm system.Such predictors if be used in a timely manner can act as an intervention for patients during haemodialysis therapy to preventing intradialytic hypotension.