cis-Eudesmane sesquiterpene glycosides from Liriope muscari and Ophiopogon japonicus

Abstract

Two new <i>cis</i>-eudesmane sesquiterpene glycosides, liriopeoside A (<b>1</b>) and ophiopogonoside A (<b>2</b>), were extracted and purified from tubers of <i>Liriope muscari</i> and <i>Ophiopogon japonicus</i>, respectively, along with three known compounds. Their structures were elucidated as 1β,6β-dihydroxy-<i>cis</i>-eudesm-3-ene-6-O-β-d-glucopyranoside (<b>1</b>) and 1β,4β,6β-trihydroxy-<i>cis</i>-eudesmane-6-O-β-d-glucopyranoside (<b>2</b>) by spectral data analysis. The structure and the relative configuration of compound <b>1</b> were confirmed by X-ray crystallographic analysis. This is the first time that <i>cis</i>-eudesmane-type sesquiterpenes have been reported from the genera <i>Ophiopogon</i> and <i>Liriope</i>.