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|Title:||ω-Phosphinyl-α-amino acids: Synthesis, and development towards use as therapeutic agents||Author(s):||Bligh, Annie Sim Wan||Author(s):||Wardle, N. J.
Hudson, H. R.
|Issue Date:||2007||Publisher:||Bentham Science||Journal:||Current Organic Chemistry||Volume:||11||Issue:||18||Start page:||1635||End page:||1651||Abstract:||
Literature publications (up to September 2006) concerning the synthesis of ω-phosphinyl-α-amino acids and their development towards use as therapeutic agents are reviewed. General and asymmetric methodologies for the preparation of straight-chain examples are described, including AP3-7 modulators of glutamate-responsive excitatory amino acid (EAA) receptors (i.e. ionotropic NMDA-, and metabotropic GrpIII mGlu-receptors), and the glutamate synthetase inhibitor phosphinothricin. Focusing primarily on the development of methods for introducing phosphonate and aminocarboxylate functions to the appropriate scaffold, approaches to conformationally constrained ω-phosphinyl-α-amino acids are also investigated, along with their relevance to the development of therapeutic regimens towards neurodegenerative disorders.
|URI:||https://repository.cihe.edu.hk/jspui/handle/cihe/2014||DOI:||10.2174/138527207783221200||CIHE Affiliated Publication:||No|
|Appears in Collections:||HS Publication|
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