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Title: ω-Phosphinyl-α-amino acids: Synthesis, and development towards use as therapeutic agents
Author(s): Bligh, Annie Sim Wan 
Author(s): Wardle, N. J.
Hudson, H. R.
Issue Date: 2007
Publisher: Bentham Science
Journal: Current Organic Chemistry 
Volume: 11
Issue: 18
Start page: 1635
End page: 1651
Literature publications (up to September 2006) concerning the synthesis of ω-phosphinyl-α-amino acids and their development towards use as therapeutic agents are reviewed. General and asymmetric methodologies for the preparation of straight-chain examples are described, including AP3-7 modulators of glutamate-responsive excitatory amino acid (EAA) receptors (i.e. ionotropic NMDA-, and metabotropic GrpIII mGlu-receptors), and the glutamate synthetase inhibitor phosphinothricin. Focusing primarily on the development of methods for introducing phosphonate and aminocarboxylate functions to the appropriate scaffold, approaches to conformationally constrained ω-phosphinyl-α-amino acids are also investigated, along with their relevance to the development of therapeutic regimens towards neurodegenerative disorders.
DOI: 10.2174/138527207783221200
CIHE Affiliated Publication: No
Appears in Collections:HS Publication

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