Please use this identifier to cite or link to this item:
|Title:||Electrosprayed core-shell nanoparticles of PVP and shellac for furnishing biphasic controlled release of ferulic acid||Author(s):||Bligh, Annie Sim Wan||Author(s):||Cui, L.
|Issue Date:||2014||Publisher:||Springer||Journal:||Colloid and Polymer Science||Volume:||292||Issue:||9||Start page:||2089||End page:||2096||Abstract:||
Coaxial electrospraying was explored to organize polymer excipients in a core-shell manner for providing biphasic controlled release of active ingredient. With ferulic acid (FA) as a model drug, and shellac and polyvinylpyrrolidone (PVP) as the core and shell polymeric matrices, core-shell nanoparticles were successfully fabricated. A series of tests were carried out to characterize the prepared core-shell nanoparticles and also the nanoparticles prepared using a single fluid electrospraying of the shell or core fluids alone. The core-shell nanoparticles had an average diameter of 530 ± 80 nm with clear core-shell structure. The contained FA was converted to an amorphous state both in the core and the shell parts due to the favorable hydrogen bonding between the components. In vitro dissolution tests demonstrated that the core-shell nanoparticles were able to provide the desired biphasic drug-controlled release profiles. Coaxial electrospraying is a useful tool for the development of novel nanodrug delivery systems from polymers.
|URI:||https://repository.cihe.edu.hk/jspui/handle/cihe/1499||DOI:||10.1007/s00396-014-3226-8||CIHE Affiliated Publication:||No|
|Appears in Collections:||HS Publication|
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.