Please use this identifier to cite or link to this item: https://repository.cihe.edu.hk/jspui/handle/cihe/1498
Title: Structure of a homofructosan from Saussurea costus and anti-complementary activity of its sulfated derivatives
Author(s): Bligh, Annie Sim Wan 
Author(s): Fan, H.
Liu, F.
Shi, S.
Wang, S.
Issue Date: 2014
Publisher: Elsevier
Journal: Carbohydrate Polymers 
Volume: 105
Start page: 152
End page: 160
Abstract: 
A homogeneous water-soluble polysaccharide APS-W1, (2 → 1)-β-d-fructofuranosan, with an average molecular weight of 3.9 kDa, was isolated and characterized from the roots of Saussurea costus. Five sulfated derivatives of APS-W1 with different degrees of sulfation were prepared and they showed strong inhibitory effect on the complement activation through the classical pathway (CP50: 2.2–18.9 μg/mL; 8.3 μg/mL for heparin) and alternative pathway (AP50: 11.4–115.8 μg/mL; 89.2 μg/mL for heparin). Mechanism studies by using complement-depleted sera indicated that sulfated derivatives with different positions of sulfation targeted to different complement proteins. Meanwhile the sulfated derivatives have limited anticoagulant effect based on re-calcification time and thrombin time. These results suggested that the sulfated derivatives prepared from APS-W1 could be promising potential complement inhibitors for the treatment of diseases caused by an over-activated complement system.
URI: https://repository.cihe.edu.hk/jspui/handle/cihe/1498
DOI: 10.1016/j.carbpol.2014.01.084
CIHE Affiliated Publication: No
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