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Title: Quinolone alkaloids from Fructus Euodiae show activity against methicillin-resistant Staphylococcus aureus
Author(s): Bligh, Annie Sim Wan 
Author(s): Pan, X.
Smith, E.
Issue Date: 2014
Publisher: Wiley
Journal: Phytotherapy Research 
Volume: 28
Issue: 2
Start page: 305
End page: 307
Fructus Euodiae is used in Traditional Chinese Medicine to treat infection. In this study, four of the quinolone alkaloids isolated from Fructus Euodiae showed activity against methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) were 8–128 µg/mL, which were equivalent to or lower than the control antibiotics, oxacillin, erythromycin and tetracycline (MIC ≥128 µg/mL). Among these isolated quinolone alkaloids, evocarpine with a 13 carbon alkenyl chain substituent at position-2 showed the best activity against MRSA. This study has demonstrated the potential of quinolone alkaloids from Fructus Euodiae as anti-MRSA compounds and supports the traditional use of the fruit as a treatment for bacterial infections.
DOI: 10.1002/ptr.4987
CIHE Affiliated Publication: No
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