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|Title:||Quinolone alkaloids from Fructus Euodiae show activity against methicillin-resistant Staphylococcus aureus||Author(s):||Bligh, Annie Sim Wan||Author(s):||Pan, X.
|Issue Date:||2014||Publisher:||Wiley||Journal:||Phytotherapy Research||Volume:||28||Issue:||2||Start page:||305||End page:||307||Abstract:||
Fructus Euodiae is used in Traditional Chinese Medicine to treat infection. In this study, four of the quinolone alkaloids isolated from Fructus Euodiae showed activity against methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) were 8–128 µg/mL, which were equivalent to or lower than the control antibiotics, oxacillin, erythromycin and tetracycline (MIC ≥128 µg/mL). Among these isolated quinolone alkaloids, evocarpine with a 13 carbon alkenyl chain substituent at position-2 showed the best activity against MRSA. This study has demonstrated the potential of quinolone alkaloids from Fructus Euodiae as anti-MRSA compounds and supports the traditional use of the fruit as a treatment for bacterial infections.
|URI:||https://repository.cihe.edu.hk/jspui/handle/cihe/1493||DOI:||10.1002/ptr.4987||CIHE Affiliated Publication:||No|
|Appears in Collections:||HS Publication|
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