Please use this identifier to cite or link to this item: https://repository.cihe.edu.hk/jspui/handle/cihe/579
DC FieldValueLanguage
dc.contributor.authorWang, Debby Danen_US
dc.date.accessioned2021-05-06T08:41:59Z-
dc.date.available2021-05-06T08:41:59Z-
dc.date.issued2016-
dc.identifier.urihttps://repository.cihe.edu.hk/jspui/handle/cihe/579-
dc.description.abstractEpidermal growth factor receptor (EGFR) mutation is a pathogenic factor of non-small cell lung cancer (NSCLC). Tyrosine kinase inhibitors (TKIs), such as gefitinib, are widely used in NSCLC treatment. In this work, we investigated the relationship between the number of EGFR residues connected with gefitinib and the response level for each EGFR mutation type. Three-dimensional trimmed Delaunay triangulation was applied to construct connections between EGFR residues and gefitinib atoms. Through molecular dynamics (MD) simulations, we discovered that when the number of EGFR residues connected with gefitinib increases, the response level of the corresponding EGFR mutation tends to descend.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofChemical Physics Lettersen_US
dc.titleAnalysis of the relationship between lung cancer drug response level and atom connectivity dynamics based on trimmed Delaunay triangulationen_US
dc.typejournal articleen_US
dc.identifier.doi10.1016/j.cplett.2016.04.056-
dc.contributor.affiliationSchool of Health Sciencesen_US
dc.relation.issn0009-2614en_US
dc.description.volume652en_US
dc.description.startpage117en_US
dc.description.endpage122en_US
dc.cihe.affiliatedYes-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairetypejournal article-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
crisitem.author.deptYam Pak Charitable Foundation School of Computing and Information Sciences-
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