Please use this identifier to cite or link to this item:
https://repository.cihe.edu.hk/jspui/handle/cihe/2030
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bligh, Annie Sim Wan | en_US |
dc.contributor.other | Bashall, A. | - |
dc.contributor.other | Garrud, C. | - |
dc.contributor.other | McPartlin, M. | - |
dc.contributor.other | Wardle, N. | - |
dc.contributor.other | White, K. | - |
dc.contributor.other | Padhye, S. | - |
dc.contributor.other | Barve, V. | - |
dc.contributor.other | Kundu, G. | - |
dc.date.accessioned | 2021-12-10T03:18:25Z | - |
dc.date.available | 2021-12-10T03:18:25Z | - |
dc.date.issued | 2003 | - |
dc.identifier.uri | https://repository.cihe.edu.hk/jspui/handle/cihe/2030 | - |
dc.description.abstract | <sup>1</sup> H NMR and LC-ESI-MS studies of the interaction between nucleosides (adenosine, cytidine, guanosine, uridine and thymidine) and a monocation platinum(II) complex [Pt(<i>C</i>-(6-aminomethylpyridin-2-yl)methylamine)Cl]<sup>+</sup> (<b>1</b>) shows it forms platinum(II) complexes with A, G and C at pH 6 and with T and U at pH 9. The X-ray structure of <b>1</b> as the hydrated chloride salt shows extensive hydrogen bonding. Amongst a series of related complexes <b>1</b> shows a strong interaction with DNA, demonstrated by inhibition of binding by the intercalator ethidium bromide, and moderate cytotoxicity. The interaction with nucleosides and the structural data suggest that <b>1</b> disrupts the DNA structure by coordinate covalent interaction and hydrogen bonding rather than simple intercalation. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.relation.ispartof | Dalton Transactions | en_US |
dc.title | Reaction of (C-(6-aminomethyl-pyridin-2-yl)methylamine)chloroplatinum(ii) with nucleosides and its biological activity | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1039/B208790A | - |
dc.contributor.affiliation | School of Health Sciences | en_US |
dc.relation.issn | 1477-9234 | en_US |
dc.description.issue | 2 | en_US |
dc.description.startpage | 184 | en_US |
dc.description.endpage | 188 | en_US |
dc.cihe.affiliated | No | - |
item.openairetype | journal article | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | School of Health Sciences | - |
crisitem.author.orcid | 0000-0002-4757-2159 | - |
Appears in Collections: | HS Publication |
Files in This Item:
File | Description | Size | Format | |
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Check Library Catalogue | 115 B | HTML | View/Open |
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