Please use this identifier to cite or link to this item: https://repository.cihe.edu.hk/jspui/handle/cihe/2030
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dc.contributor.authorBligh, Annie Sim Wanen_US
dc.contributor.otherBashall, A.-
dc.contributor.otherGarrud, C.-
dc.contributor.otherMcPartlin, M.-
dc.contributor.otherWardle, N.-
dc.contributor.otherWhite, K.-
dc.contributor.otherPadhye, S.-
dc.contributor.otherBarve, V.-
dc.contributor.otherKundu, G.-
dc.date.accessioned2021-12-10T03:18:25Z-
dc.date.available2021-12-10T03:18:25Z-
dc.date.issued2003-
dc.identifier.urihttps://repository.cihe.edu.hk/jspui/handle/cihe/2030-
dc.description.abstract<sup>1</sup> H NMR and LC-ESI-MS studies of the interaction between nucleosides (adenosine, cytidine, guanosine, uridine and thymidine) and a monocation platinum(II) complex [Pt(<i>C</i>-(6-aminomethylpyridin-2-yl)methylamine)Cl]<sup>+</sup> (<b>1</b>) shows it forms platinum(II) complexes with A, G and C at pH 6 and with T and U at pH 9. The X-ray structure of <b>1</b> as the hydrated chloride salt shows extensive hydrogen bonding. Amongst a series of related complexes <b>1</b> shows a strong interaction with DNA, demonstrated by inhibition of binding by the intercalator ethidium bromide, and moderate cytotoxicity. The interaction with nucleosides and the structural data suggest that <b>1</b> disrupts the DNA structure by coordinate covalent interaction and hydrogen bonding rather than simple intercalation.en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofDalton Transactionsen_US
dc.titleReaction of (C-(6-aminomethyl-pyridin-2-yl)methylamine)chloroplatinum(ii) with nucleosides and its biological activityen_US
dc.typejournal articleen_US
dc.identifier.doi10.1039/B208790A-
dc.contributor.affiliationSchool of Health Sciencesen_US
dc.relation.issn1477-9234en_US
dc.description.issue2en_US
dc.description.startpage184en_US
dc.description.endpage188en_US
dc.cihe.affiliatedNo-
item.openairetypejournal article-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptSchool of Health Sciences-
crisitem.author.orcid0000-0002-4757-2159-
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