Synthesis and anti-cancer evaluation of cyclotriphosphazene hydrazone derivatives

Abstract

Hexasubstituted cyclotriphosphazene hydrazones [N₃P₃(-OC₆H₄-p-CH=N-NH-C(O)-C₆H₄-p-X)₆] were prepared by the reaction of hexachlorocyclotriphosphazene with N'-(4- hydroxybenzylidene)-4-substituted-benzohydrazides [HO-C₆H₄-p-CH=N-NH-C(O)-C₆H₄-p-X]. The structures were confirmed by elemental analysis, FT-IR, ¹H, ¹³C, ³¹P NMR and mass spectrometry. These cyclic model systems bearing hydrolysable hydrazone linkages were evaluated for their antiproliferative activity in vitro against the human liver carcinoma cell line (HepG2) and Human cervix carcinoma cell line (HeLa).